ACT Ambulance, ACT Fire & Rescue and ACT Policing are on scene at a motor vehicle incident on the Monaro Highway (southbound), 500m south of Newcastle Street at Fyshwick.
Firefighters are working to stabilise the vehicle which has gone over the embankment.
No reports of injuries from the scene.
There will be significant traffic delays in the area while firefighters and ACT Roads crews recover the vehicle.
The community is asked to avoid the area.